T = Technician, U = Undergraduate Student, G = Graduate Student, P = Postdoctoral Fellow
2017
Ghosh, B.G, Tsao, T. W.G, & Czajkowski, C. (2017). A chimeric prokaryotic-eukaryotic pentameric ligand gated ion channel reveals interactions between the extracellular and transmembrane domains shape neurosteroid modulation. Neuropharmacology, 125, 343–352. https://doi.org/10.1016/j.neuropharm.2017.08.007 PubMed
2014
Ding, Y., Dellisanti, C. D.P, Ko, M. H., Czajkowski, C., & Puglielli, L. (2014). The Endoplasmic Reticulum-based Acetyltransferases, ATase1 and ATase2, Associate with the Oligosaccharyltransferase to Acetylate Correctly Folded Polypeptides. Journal of Biological Chemistry , 289(46), 32044–32055. https://doi.org/10.1074/jbc.M114.585547 PubMed
2013
Laha, K.T., Ghosh, BG and Czajkowski, C. (2013) Macroscopic Kinetics of Pentameric Ligand Gated Ion Channels: Comparisons between Two Prokaryotic Channels and One Eukaryotic Channel. PLoS ONE 8(11): e80322. doi:10.1371/journal.pone.0080322 PubMed
Dellisanti CDP, Ghosh BG, Hanson SM, Raspanti JM, Grant VA, Diarra GM, Schuh AMU, Satyshur K, Klug CS and Czajkowski C (2013). Site-directed spin labeling reveals pentameric ligand-gated ion channel gating motions. PLoS Biol 11(11): e1001714. PubMed
Ghosh BG and Czajkowski C (2013). Propofol binding to the resting state of the Gloeobacter violaceus ligand gated ion channel (GLIC) induces structural changes in the inter and intra-subunit trans-membrane domain (TMD) cavities. J. Biol. Chem. 288: 17420-17431.
2012
Venkatachalan SP and Czajkowski, C. (2012) A structural link between the GABA receptor’s agonist binding site and inner b-sheet governs channel activation and allosteric drug modulation. J. Biol. Chem. doi:10.1074/jbc.M111.316836 PubMed
2011
Morlock, E. V. and Czajkowski, C. (2011) Different residues in the GABA-A receptor benzodiazepine binding pocket mediate benzodiazepine efficacy and binding. Mol. Pharmacol. 80: 14-22 PMCID: PMC3127544 PubMed
Dellisanti, C.D.P, Hanson, S.M., Chen, L. and Czajkowski, C. (2011) Packing of the extracellular domain hydrophobic core has evolved to facilitate pentameric ligand-gated ion channel function. J. Biol. Chem. 286: 3658-3670. PMCID: PMC3030369 PubMed
Sancar, F. and Czajkowski, C. (2011) Allosteric modulators induce distinct movements at the GABA-binding site interface of the GABA-A receptor. Neuropharmacology 60:520-528. PMCID: PMC3026633 PubMed
Hanson, S.M. and Czajkowski, C. (2011) Disulfide trapping of the GABA-A receptor reveals the importance of the coupling interface in benzodiazepine action. British J. Pharmacol. 162:673-687. doi:10.1111/j.1476-5381.2010.01073.x PMC Journal PubMed
2010
Wagoner, K.R. and Czajkowski, C. (2010) Stoichiometry of Expressed a4b2d g-aminobuytric acid type A receptors depends on the ratio of subunit unit cDNA transfected. J. Biol. Chem. 285: 14187-14194 PMCID: PMC2863200 PubMed
Boileau, A.J., Pearce, R. A. and Czajkowski, C. (2010) The short splice variant of the g2 subunit acts as an external modulator of GABAA receptor function. J. Neurosci. 30: 4895-4903 PMCID: PMC2891256 PubMed
2009
Muroi, Y., Theusch, C.M.G, P, Czajkowski, C., and Jackson, M.B. (2009) Distinct structural changes in the GABA-A receptor elicited by pentobarbital and GABA. Biophysical Journal. 96: 499-509. PMCID: PMC2716461 PubMed
2008
Hanson, S.M., Morlock, E.V., Satyshur, K.A., and Czajkowski, C. (2008) Structural requirements for eszopiclone and zolpidem binding to the GABAA receptor are different. J. Med. Chem. 51: 7243-7252. PMCID: PMC2645942 PubMed
Venkatachalan, S. and Czajkowski, C. (2008) A conserved salt-bridge critical for GABAA receptor function and loop C dynamics. Proc. Natl. Acad. Sci. 105: 13604-13609. PMCID: PMC2533236 PubMed
Sharkey LM. and Czajkowski C. (2008) Individually monitoring ligand-induced changes in the structure of the GABAA receptor at benzodiazepine binding site and non-binding-site interfaces. Mol Pharmacol. 2008 Jul;74(1):203-12. Epub 2008 Apr 18. PubMed
Mercado J. and Czajkowski C. (2008) Gamma-aminobutyric acid (GABA) and pentobarbital induce different conformational rearrangements in the GABA A receptor alpha1 and beta2 pre-M1 regions. J Biol Chem. May 30;283(22):15250-7. Epub 2008 Apr 3. PubMed
Hanson SM, Czajkowski C. (2008) Structural mechanisms underlying benzodiazepine modulation of the GABA(A) receptor. J Neurosci. 2008 Mar 26;28(13):3490-9. PubMed
2007
Sancar, F., Ericksen, S.S., Kucken, A.M., Teissere, J.A. and Czajkowski, C. (2007) Structural determinants for high affinity zolpidem binding to GABA-A receptors. Mol. Pharmacol 71: 38-46. Epub 2006 Sep 29. PubMed
Kloda, J. H. and Czajkowski, C. (2007) Agonist-, antagonist-, and benzodiazepine-induced structural changes in the a1Met113-Leu132 region of the GABA-A receptor. Mol. Pharmacol 71: 483-493. Epub 2006 Nov 15. PubMed
2006
Muroi Y, Czajkowski C, Jackson MB. (2006) Local and Global Ligand-Induced Changes in the Structure of the GABA(A) Receptor. Biochemistry Jun 13;45(23):7013-22. PMID: 16752892 PubMed
Mercado J, Czajkowski C. (2006) Charged residues in the alpha1 and beta2 pre-M1 regions involved in GABAA receptor activation. J Neurosci. Feb 15;26(7):2031-40. PMID: 16481436 PubMed
2005
Boileau AJ, Pearce RA, Czajkowski C. (2005) Tandem subunits effectively constrain GABAA receptor stoichiometry and recapitulate receptor kinetics but are insensitive to GABAA receptor-associated protein. J Neurosci. Dec 7;25(49):11219-30. PMID: 16339017 PubMed
Czajkowski C. (2005) Neurobiology: triggers for channel opening. Nature. Nov 10;438(7065):167-8. PubMed
2004
Wagner, D.A., Czajkowski, C., and Jones, M.V. (2004) An arginine involved in GABA binding and unbinding but not gating of the GABA-A receptor. J. Neurosci. 24: 2733-2741. PubMed
Sancar, F. and Czajkowski, C. (2004) A GABA-A receptor mutation linked to human epilepsy (g2 R43Q) impairs cell surface expression of abg receptors. J. Biol. Chem. 279: 47034-47039.
Newell, J. G., McDevitt, and Czajkowski, C. (2004) Mutation of glutamate 155 of the GABA-A receptor b2 subunit produces a spontaneously open channel: A trigger for channel activation. J. Neurosci. 24: 11226-11235. PubMed